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KMID : 0366220140490020115
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Korean Journal of Hematology
2014 Volume.49 No. 2 p.115 ~ p.119
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Abbreviated chemotherapy for limited-stage diffuse large B-cell lymphoma after complete resection
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Jo Jung-Min
Yoon Dok-Hyun
Lee Kyoung-Min
Kang Eun-Hee
Kim Shin
Suh Cheol-Won
Lee Sang-Wook
Park Chan-Sik
Huh Joo-Ryung
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Abstract
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Background: Abbreviated chemotherapy followed by radiotherapy or full cycles of chemotherapy is recommended as a standard treatment for limited-stage (LS) diffuse large B-cell lympho-ma (DLBCL). After complete resection of tumors, however, Burkitt and childhood B-cell Non-Hodgkin lymphoma show favorable outcomes, even after abbreviated chemo-therapy of only 2 or 3 cycles. We investigated the effectiveness of abbreviated chemo-therapy in patients with LS DLBCL after complete tumor resection.
Methods: We retrospectively reviewed 18 patients with LS DLBCL who underwent complete tumor resection followed by either 3 or 4 cycles of chemotherapy between March 2002 and May 2010.
Results: With a median follow-up period of 57.9 months (range, 31.8?130.2 months), no patients experienced disease relapse or progression; however, 1 patient experienced secondary acute myeloid leukemia during follow-up. The 5-year progression-free survival rate and overall survival rate were 93.3% and 94.1%, respectively.
Conclusion: These results warrant further investigation into abbreviated chemotherapy as an alter-native treatment for patients who have undergone complete resection of LS DLBCL.
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KEYWORD
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Diffuse large B-cell lymphoma, Limited Stage, Resection, Abbreviated chemotherapy
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